L-Carnitine
 

What is L-Carnitine?

L-Carnitine is a water-soluble molecule essential for transporting fatty acids into the mitochondria of cells, where they are converted into energy. It is synthesized naturally from the amino acids lysine and methionine, but dietary intake can further support the body’s needs.

 

 

Function of L-Carnitine

• Fat Utilization: L-Carnitine plays a critical role in breaking down fats for energy production.

• Energy Creation During Fasting: When not eating, body fat is used for energy. L-Carnitine facilitates the transport of fatty acids to the mitochondria for this process.

• Prevention of Energy Deficits: A deficiency in L-Carnitine can starve the brain of energy, leading to dysfunction, impaired development, and increased inflammation.

• Organ Protection: L-Carnitine supports immune function and reduces oxidative damage, helping organs repair and recover from injury.
  
   

 

Effects on Autism

• High Prevalence of Deficiency: Up to 90% of children with autism show low carnitine levels, often due to genetic factors, absorption issues, or impaired production rather than inadequate dietary intake.

• Benefits of Supplementation:

  • Behavioral Improvements: Reduced hyperactivity and enhanced social-emotional awareness.

  • Cognitive Enhancements: Better memory, learning, and receptive language skills.

  • Physical Benefits: Improved muscle strength and eye contact.

  • Genetic Disorder Support: L-Carnitine has shown promise in mitigating symptoms of genetic conditions associated with autism.

• Forms of Carnitine for Supplementation:

  • L-Carnitine: The most common and effective form.

  • Acetyl-L-Carnitine (ALCAR): Better for neurological benefits due to its ability to cross the blood-brain barrier.

  • Propionyl-L-Carnitine: Primarily used for cardiovascular health.

• Side Effects: High doses may cause fishy odors (breath, sweat, urine), gastrointestinal upset, restlessness, and odorous stools.
  
   

 

Effects on Heavy Metal Toxicity

• Detoxification Support: Carnitine deficiency impairs the body’s ability to remove toxins, causing a buildup in the liver, brain, kidneys, and bloodstream.

• Symptom Management: Supplementation can alleviate issues like decreased brain function, muscle weakness, lethargy, and heart enlargement linked to toxin accumulation.
  
   

 

Foods High in Carnitine (Highest to Lowest)

1. Beef Steak

2. Ground Beef

3. Whole Milk

4. Codfish

5. Chicken Breast

6. Cheddar Cheese
   
    

 

Recommended Dosage for Children with Autism

• Typical Dosage: 50–100 mg per kilogram of body weight per day, often divided into 2–3 doses.

• Adjustments for Autism: Studies have found benefits with doses ranging from 500–2,000 mg/day, depending on the child’s weight, age, and severity of symptoms.

• Form Preference: Acetyl-L-Carnitine (ALCAR) is often recommended for neurological benefits, while L-Carnitine is used for broader metabolic support.
   

Note: Consult with a pediatrician or healthcare professional before starting L-Carnitine supplementation to determine the appropriate dose and monitor potential side effects.

 

Key Takeaways

1. Essential Role: L-Carnitine is crucial for converting fats into energy, supporting brain function, and protecting against oxidative damage and inflammation.

2. Deficiency in Autism: Up to 90% of children with autism experience carnitine deficiency, often linked to genetic factors or impaired absorption, not diet.

3. Supplementation Benefits:

• Improves behavior, cognitive abilities, muscle strength, and social-emotional awareness.

• Supports children with genetic conditions associated with autism.

• Enhances detoxification and reduces heavy metal buildup.